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In animal models, blocking IL-1 signaling (e.g., with anti-IL-1R antibodies) ameliorates Candida -exacerbated colitis (Li X.V

Together, these findings suggest that age-dependent decrease in BDNF signaling may cause synaptic alterations through an initial and preferential effect on GABA presynaptic genes

It has been described as an insulin-mimetic, as it stimulates lipogenesis and glucose uptake in adipocytes through mechanisms like insulin